منابع مشابه
Ablation of the p16INK4a tumour suppressor reverses ageing phenotypes of klotho mice
The p16(INK4a) tumour suppressor has an established role in the implementation of cellular senescence in stem/progenitor cells, which is thought to contribute to organismal ageing. However, since p16(INK4a) knockout mice die prematurely from cancer, whether p16(INK4a) reduces longevity remains unclear. Here we show that, in mutant mice homozygous for a hypomorphic allele of the α-klotho ageing-...
متن کاملKlotho
The Klotho gene codes for a type-i membrane protein that exists in two forms—as a transmembrane protein and as a secreted protein. Particularly the secreted form of Klotho suppresses oxidative stress and growth factor signaling and regulates ion channels and transporters. it was reported that Klotho overexpression suppresses insulin/iGF-1 signaling. This signaling pathway was indicated as a cen...
متن کاملKlotho gene polymorphisms and their association with sickle cell disease phenotypes
e read with great interest the recent review presented by de ouza Pacheco and Goncalves,1 and we would like to briefly eport our experience with Klotho (KL) single nucleotide polyorphisms (SNPs) and sickle cell disease (SCD). SCD presents a phenotypic heterogeneity that has not een fully elucidated yet. Genetic modifiers and environmenal effects may account for the different clinical outcomes b...
متن کاملCalpain 1 inhibitor BDA-410 ameliorates α-klotho-deficiency phenotypes resembling human aging-related syndromes
Taking good care of elderly is a major challenge of our society, and thus identification of potential drug targets to reduce age-associated disease burden is desirable. α-klotho(-/-) (α-kl) is a short-lived mouse model that displays multiple phenotypes resembling human aging-related syndromes. Such ageing phenotype of α-kl(-/-) mice is associated with activation of a proteolytic enzyme, Calpain...
متن کاملPhosphate and Klotho
Klotho is a putative aging suppressor gene encoding a single-pass transmembrane co-receptor that makes the fibroblast growth factor (FGF) receptor specific for FGF-23. In addition to multiple endocrine organs, Klotho is expressed in kidney distal convoluted tubules and parathyroid cells, mediating the role of FGF-23 in bone-kidney-parathyroid control of phosphate and calcium. Klotho(-/-)mice di...
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ژورنال
عنوان ژورنال: Aging
سال: 2019
ISSN: 1945-4589
DOI: 10.18632/aging.102117